abstract：BACKGROUND:A limited number of mutations in the GH secretagogue receptor gene (GHSR) have been described in patients with short stature. Objective To analyze GHSR in idiopathic short stature (ISS) children including a subgroup of constitutional delay of growth and puberty (CDGP) patients. SUBJECTS AND METHODS:The GHSR...

journal_title：European journal of endocrinology

authors： Pugliese-Pires PN,Fortin JP,Arthur T,Latronico AC,Mendonca BB,Villares SM,Arnhold IJ,Kopin AS,Jorge AA

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Ghrelin is a peptide mainly secreted by gastric mucosa and has been implicated in the regulation of eating behavior and weight balance. Obesity and Helicobacter pylori infection are associated with changes in plasma ghrelin levels. OBJECTIVE:This study was designed to evaluate the density of ghrelin-produci...

journal_title：European journal of endocrinology

authors： Maksud FA,Alves JS,Diniz MT,Barbosa AJ

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:Cardiovascular disease (CVD) occurs frequently and may progress more rapidly in overt hypothyroidism (OVH). However, the role of mild thyroid failure as a risk factor for CVD is not clear. This study is aimed at exploring the association between subclinical hypothyroidism (SCH) and coronary artery disease (CA...

journal_title：European journal of endocrinology

authors： Park YJ,Lee YJ,Choi SI,Chun EJ,Jang HC,Chang HJ

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Familial neurohypophyseal (central) diabetes insipidus (DI) is caused by mutations in the arginine vasopressin-neurophysin II (AVP-NPII) gene. The majority of cases is inherited in an autosomal dominant way. In this study, we present the clinical features of a mother and her son with autosomal dominant neuro...

journal_title：European journal of endocrinology

authors： de Fost M,van Trotsenburg AS,van Santen HM,Endert E,van den Elzen C,Kamsteeg EJ,Swaab DF,Fliers E

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:Adult height deficit seen in Turner syndrome (TS) originates, in part, from growth retardation in utero and throughout the first 3 years of life. Earlier diagnosis enables earlier therapeutic intervention, such as with recombinant human GH (r-hGH), which may help to prevent growth retardation. In this open-la...

journal_title：European journal of endocrinology

authors： Linglart A,Cabrol S,Berlier P,Stuckens C,Wagner K,de Kerdanet M,Limoni C,Carel JC,Chaussain JL,French Collaborative Young Turner Study Group.

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:Neck and thorax single photon emission computed tomography with computed tomography (SPECT-CT) improves the reliability of postablation (131)I whole-body scan (WBS) for differentiated thyroid cancer (DTC). The aim of this study was to assess the prognostic value for persistent or recurrent disease of postabla...

journal_title：European journal of endocrinology

authors： Ciappuccini R,Heutte N,Trzepla G,Rame JP,Vaur D,Aide N,Bardet S

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVES:The French Acromegaly Registry records data of acromegalic patients' since 1992 in French, Belgian (Liège), and Swiss (Lausanne) centers. We studied the prevalence of diabetes in this population looking for risk factors. Patients from one of the centers (Reims) were then analyzed more thoroughly. METHODS:Th...

journal_title：European journal of endocrinology

authors： Fieffe S,Morange I,Petrossians P,Chanson P,Rohmer V,Cortet C,Borson-Chazot F,Brue T,Delemer B,French Acromegaly Registry.

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Few published data link overweight and obesity with measures of quality of life (QoL) including sexual health in men. OBJECTIVE:To assess the association of overweight/obesity with impairment of physical and psychological QoL and sexual functions in men. DESIGN AND SETTING:Cross-sectional, multicentre surv...

journal_title：European journal of endocrinology

authors： Han TS,Tajar A,O'Neill TW,Jiang M,Bartfai G,Boonen S,Casanueva F,Finn JD,Forti G,Giwercman A,Huhtaniemi IT,Kula K,Pendleton N,Punab M,Silman AJ,Vanderschueren D,Lean ME,Wu FC,EMAS group.

更新日期：2011-06-01 00:00:00

abstract：CONTEXT:The late presentation of steroid 5α-reductase-2 (SRD5A2) deficiency in females is poorly characterised. The ratios of 5α/5β-reduced metabolites of adrenal steroids in a urine steroid profile (USP) can give an indication of SRD5A2 deficiency, although the diagnostic cut-off for 5α/5β ratios are not clearly defin...

journal_title：European journal of endocrinology

authors： Berra M,Williams EL,Muroni B,Creighton SM,Honour JW,Rumsby G,Conway GS

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:We examined the hypothesis that high FGF-23 levels early after transplantation contribute to the onset of hypophosphatemia, independently of parathyroid hormone (PTH) and other factors regulating phosphate metabolism. METHODS:We measured serum phosphate levels (sPi), renal tubular reabsorption of Pi (TmPi/G...

journal_title：European journal of endocrinology

authors： Trombetti A,Richert L,Hadaya K,Graf JD,Herrmann FR,Ferrari SL,Martin PY,Rizzoli R

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:Mutations in HESX1 represent a rare cause of GH deficiency (GHD) associated with a broad spectrum of other anomalies. We searched for causative mutations in a cohort of 244 Italian patients affected by combined and isolated GHD (IGHD). METHODS:The HESX1 gene-coding region and exon-intron boundaries were scre...

journal_title：European journal of endocrinology

authors： Vivenza D,Godi M,Faienza MF,Mellone S,Moia S,Rapa A,Petri A,Bellone S,Riccomagno S,Cavallo L,Giordano M,Bona G

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:Circulating IGF1 declines with age while ill-health increases. Controversy remains whether differences in the levels of IGF1 and its binding proteins 1 and 3 (IGFBP1 and IGFBP3) determine health outcomes during ageing. We examined associations of IGF1, IGFBP1 and IGFBP3 with all-cause and cardiovascular morta...

journal_title：European journal of endocrinology

authors： Yeap BB,Chubb SA,McCaul KA,Ho KK,Hankey GJ,Norman PE,Flicker L

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:Pretibial myxedema (PM) is a manifestation of Graves' disease (GD). Currently, its diagnosis depends on physicians' observation and biopsy. No satisfactory, objective, and non-invasive tool is available to record and investigate lesions. Digital infrared thermal imaging (DITI) detects surface temperature, and...

journal_title：European journal of endocrinology

authors： Shih SR,Lin MS,Li HY,Yang HY,Hsiao YL,Chang MT,Chen CM,Chang TC

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:17α-Hydroxylase/17,20-lyase deficiency (17OHD) caused by a mutation in the CYP17A1 gene is characterized by hypertension, hypokalemia, and abnormal development of the genitalia. The majority of CYP17A1 mutations are located in the coding sequence, and several intronic splicing site mutations have been report...

journal_title：European journal of endocrinology

authors： Qiao J,Han B,Liu BL,Liu W,Wu JJ,Pan CM,Jiang H,Gu T,Jiang BR,Zhu H,Lu YL,Wu WL,Chen MD,Song HD

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:The treatment of children with subclinical hypothyroidism (SH) is controversial for TSH values between 4.5 and 10 mU/l. The aim of this cross-sectional, controlled study was to evaluate growth and intellectual outcome in children with persistent SH who have never been treated with levothyroxine. DESIGN AND M...

journal_title：European journal of endocrinology

authors： Cerbone M,Bravaccio C,Capalbo D,Polizzi M,Wasniewska M,Cioffi D,Improda N,Valenzise M,Bruzzese D,De Luca F,Salerno M

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of coadministered lanreotide Autogel (LA; 120  mg/month) and pegvisomant (40-120  mg/week) in acromegaly. DESIGN:This is a 28-week, multicenter, open-label, single-arm sequential study. METHODS:Patients (n=92) biochemically uncontrolled, on somatostatin analogs (SSAs) or ...

journal_title：European journal of endocrinology

authors： van der Lely AJ,Bernabeu I,Cap J,Caron P,Colao A,Marek J,Neggers S,Birman P

更新日期：2011-03-01 00:00:00

abstract：CONTEXT:CDKN1B encodes the cyclin-dependent kinase inhibitor p27Kip1 and is mutated in multiple endocrine neoplasia-like syndromes. CDKN1B also harbors single nucleotide polymorphisms; the T/G transversion at nucleotide 326 (the V109G variant) has been reported to be protective in breast, hereditary prostate, and pancr...

journal_title：European journal of endocrinology

authors： Pasquali D,Circelli L,Faggiano A,Pancione M,Renzullo A,Elisei R,Romei C,Accardo G,Coppola VR,De Palma M,Ferolla P,Grimaldi F,Colao A,Colantuoni V

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:To make the specificity of fluorodesoxyglucose ((18)FDG) positron emission tomography (PET) precise, in the follow-up of patients with adrenal cancer. DESIGN:This single centre retrospective study assessed the frequency and outcome of (18)FDG uptake in the remaining adrenal glands after adrenalectomy for adr...

journal_title：European journal of endocrinology

authors： Leboulleux S,Deandreis D,Escourrou C,Al Ghuzlan A,Bidault F,Aupérin A,Travagli JP,Lumbroso J,Schlumberger M,Baudin E

更新日期：2011-01-01 00:00:00

abstract：CONTEXT:It is unknown whether the metabolic effects of the removal of an adrenal incidentaloma (AI) can be predicted by the assessment of cortisol hypersecretion before surgery. OBJECTIVE:To evaluate the accuracy of several criteria of hypothalamic-pituitary-adrenal axis activity in predicting the metabolic outcome af...

journal_title：European journal of endocrinology

authors： Eller-Vainicher C,Morelli V,Salcuni AS,Battista C,Torlontano M,Coletti F,Iorio L,Cairoli E,Beck-Peccoz P,Arosio M,Ambrosi B,Scillitani A,Chiodini I

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:Smaller size at birth has been associated with an increased risk of metabolic and cardiovascular disorders in adult life. Fetal programming of the hypothalamic-pituitary-adrenal axis has been suggested as a possible explanation. Fetal glucocorticoid (GC) overexposure has effects that suggest a role of GCs in ...

journal_title：European journal of endocrinology

authors： Manenschijn L,van den Akker EL,Ester WA,Leunissen RW,Willemsen RH,van Rossum EF,Koper JW,Lamberts SW,Hokken-Koelega AC

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:Cushing's disease (CD) is usually caused by ACTH-secreting pituitary microadenomas, while silent corticotroph adenomas (SCA) are macroadenomas without Cushingoid features. However, the molecular mechanism(s) underlying their different tumor growth remains unknown. The aim of the current study was to evaluate ...

journal_title：European journal of endocrinology

authors： Tani Y,Inoshita N,Sugiyama T,Kato M,Yamada S,Shichiri M,Hirata Y

更新日期：2010-10-01 00:00:00

abstract：:Nelson's syndrome is a potentially life-threatening condition that does not infrequently develop following total bilateral adrenalectomy (TBA) for the treatment of Cushing's disease. In this review article, we discuss some controversial aspects of Nelson's syndrome including diagnosis, predictive factors, aetiology, p...

journal_title：European journal of endocrinology

authors： Barber TM,Adams E,Ansorge O,Byrne JV,Karavitaki N,Wass JA

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:Both animal and human studies have associated the endocannabinoid system with obesity and markers of metabolic dysfunction. Blockade of the cannabinoid receptor 1 (CB1) caused weight loss and reduction in waist size in both obese and type II diabetics. Recent studies on common variants of the CB1 receptor gen...

journal_title：European journal of endocrinology

authors： Frost M,Nielsen TL,Wraae K,Hagen C,Piters E,Beckers S,De Freitas F,Brixen K,Van Hul W,Andersen M

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:The type 2 deiodinase (D2) is a key enzyme for intracellular triiodothyronine (T(3)) generation. A single-nucleotide polymorphism in D2 (Thr92Ala) has been associated with increased insulin resistance in nondiabetic and type 2 diabetes (DM2) subjects. Our aim was to evaluate whether the D2 Thr92Ala polymorphi...

journal_title：European journal of endocrinology

authors： Dora JM,Machado WE,Rheinheimer J,Crispim D,Maia AL

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND AND AIM:Several basic science studies support the existence of non-genomic glucocorticoid signaling in pancreas, liver, and adipocytes, but its clinical relevance has not yet been elucidated. This study aimed at investigating the rapid effects of hydrocortisone on the human metabolic response to glucose. SU...

journal_title：European journal of endocrinology

authors： Vila G,Krebs M,Riedl M,Baumgartner-Parzer SM,Clodi M,Maier C,Pacini G,Luger A

更新日期：2010-08-01 00:00:00

abstract：:Bone loss due to menopause, natural or artificial, has been attributed solely to low estrogen. However, in a woman's life, the most precipitous bone loss begins 2 years prior to the last menstrual period, during which time estrogen levels are unperturbed whereas FSH is elevated. Our cell-based and mouse genetic studie...

journal_title：European journal of endocrinology

authors： Iqbal J,Sun L,Zaidi M

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVE:GH deficiency (GHD) and glucocorticoid excess are associated with increased risk of fragility fractures. We aimed to evaluate whether the prevalence of vertebral fractures may be influenced by glucocorticoid over-replacement in hypopituitary males with GHD. DESIGN:Cross-sectional study. METHODS:Fifty-one ad...

journal_title：European journal of endocrinology

authors： Mazziotti G,Porcelli T,Bianchi A,Cimino V,Patelli I,Mejia C,Fusco A,Giampietro A,De Marinis L,Giustina A

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVE:FSH, via its receptor (FSHR), influences bone remodeling and osteoclast proliferation and activity. The aim of this study was to evaluate the influence of two single nucleotide polymorphisms (SNPs) of the FSHR gene on bone mineral density (BMD) and bone turnover markers (bone alkaline phosphatase and type I c...

journal_title：European journal of endocrinology

authors： Rendina D,Gianfrancesco F,De Filippo G,Merlotti D,Esposito T,Mingione A,Nuti R,Strazzullo P,Mossetti G,Gennari L

更新日期：2010-07-01 00:00:00

abstract：DESIGN:While androgens and estrogens control glucocorticoid secretion in animal models, how the sex-steroid milieu determines cortisol secretion in humans is less clear. To address this issue, cortisol was measured in archival sera obtained at 10-min intervals for 5 h in 42 healthy men administered double placebo, plac...

journal_title：European journal of endocrinology

authors： Iranmanesh A,Bowers CY,Veldhuis JD

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Somatostatin analogs (SA) are the cornerstone in the medical treatment of acromegaly, used as either primary or adjunctive therapy. In particular, SA are effective in inducing the biochemical remission of the disease and tumor shrinkage, although only few cases of complete disappearance of the pituitary tumo...

journal_title：European journal of endocrinology

authors： Auriemma RS,Galdiero M,Grasso LF,Vitale P,Cozzolino A,Lombardi G,Colao A,Pivonello R

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Ghrelin is an orexigenic 28-amino acid peptide produced by the stomach. Circulating ghrelin levels rise shortly before and fall shortly after every meal. Peptide YY (PYY), an anorexigenic 36-amino acid peptide, is secreted primarily from the intestinal mucosa of the ileum and large intestine. Plasma...

journal_title：European journal of endocrinology

authors： Bizzarri C,Rigamonti AE,Luce A,Cappa M,Cella SG,Berini J,Sartorio A,Müller EE,Salvatoni A

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:To compare the presentation and clinical course of Graves' disease (GD) in two pediatric populations consisting of 28 patients with Down's syndrome (DS) and 109 controls without DS respectively. DESIGN AND METHODS:The evolution over time of GD was determined in both groups according to the clinical changes a...

journal_title：European journal of endocrinology

authors： De Luca F,Corrias A,Salerno M,Wasniewska M,Gastaldi R,Cassio A,Mussa A,Aversa T,Radetti G,Arrigo T

更新日期：2010-03-01 00:00:00

abstract：:Major hormonal changes emerge during pregnancy. The pituitary gland is one of the most affected organs with altered anatomy and physiology. The pituitary gland is enlarged as a result of lactotroph hyperplasia. Due to physiological changes in the pituitary and target hormone levels, binding globulins, and placental ho...

journal_title：European journal of endocrinology

authors： Karaca Z,Tanriverdi F,Unluhizarci K,Kelestimur F

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:Paraoxonase-1 (PON-1), which has PON and arylesterase activities, is a high-density lipoprotein (HDL)-bound antioxidant enzyme that inhibits atherosclerosis. Diabetes has been shown to have an impact on oxidative stress. The effect of metabolic syndrome (MetS) on oxidative stress and PON-1 has been shown befo...

journal_title：European journal of endocrinology

authors： Tabur S,Torun AN,Sabuncu T,Turan MN,Celik H,Ocak AR,Aksoy N

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:An inherited profile of genes related to the response to aggressive environmental factors such as viruses and chemicals may be related to an increased susceptibility to Graves' disease (GD). DESIGN AND METHODS:This prospective case-control study was designed to examine the relationship between human herpesvi...

journal_title：European journal of endocrinology

authors： Leite JL,Bufalo NE,Santos RB,Romaldini JH,Ward LS

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:Adiponectin and resistin have been linked to inflammation, endothelial dysfunction, and/or insulin secretion or resistance. It remains to be elucidated which of these adipokines is associated primarily with biomarkers of all or only some of these categories, i.e. biomarkers of inflammation, endothelial dysfun...

journal_title：European journal of endocrinology

authors： Fargnoli JL,Sun Q,Olenczuk D,Qi L,Zhu Y,Hu FB,Mantzoros CS

更新日期：2010-02-01 00:00:00

abstract：CONTEXT:A wide range (15-56%) of prevalences of anterior pituitary insufficiency are reported in patients after traumatic brain injury (TBI). However, different study populations, study designs, and diagnostic procedures were used. No data are available on emergency-department-based cohorts of TBI patients. OBJECTIVE:...

journal_title：European journal of endocrinology

authors： van der Eerden AW,Twickler MT,Sweep FC,Beems T,Hendricks HT,Hermus AR,Vos PE

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Adaptive alterations in maternal physiology cause changes in thyroid hormone levels throughout pregnancy, and precise biochemical evaluation is thus highly dependent on gestation-specific reference intervals and expected intra-individual variation. OBJECTIVE:The aim of the study was the assessment of the in...

journal_title：European journal of endocrinology

authors： Boas M,Forman JL,Juul A,Feldt-Rasmussen U,Skakkebaek NE,Hilsted L,Chellakooty M,Larsen T,Larsen JF,Petersen JH,Main KM

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Nateglinide restores early-phase insulin secretion to feeding and reduces postprandial hyperglycaemia in type 2 diabetes. This study evaluated the effects of nateglinide on dipeptidyl peptidase-IV (DPP-IV) activity and glucose-dependent insulinotropic polypeptide (GIP) degradation. Research design and method...

journal_title：European journal of endocrinology

authors： McKillop AM,Duffy NA,Lindsay JR,Green BD,Patterson S,O'Harte FP,Bell PM,Flatt PR

更新日期：2009-12-01 00:00:00

abstract：CONTEXT:Craniopharyngioma patients without GH therapy are at an increased cardiovascular disease (CVD) risk and particularly concerning women. No previous study on long-term GH therapy in adults with childhood onset (CO) craniopharyngioma was identified. OBJECTIVE:To investigate CVD risk in adults with CO craniopharyn...

journal_title：European journal of endocrinology

authors： Holmer H,Ekman B,Björk J,Nordstöm CH,Popovic V,Siversson A,Erfurth EM

更新日期：2009-11-01 00:00:00